Which specimens are collected and sent to the laboratory during a suspected transfusion reaction?

• A. Blood and urine specimens
• B. Only blood specimens
• C. Only urine specimens
• D. Cerebrospinal fluid

Answer: (A)

When a transfusion reaction is suspected, labs are drawn to identify whether immune-mediated hemolysis is occurring and to assess organ impact. Blood specimens are collected to evaluate the patient’s blood for signs of hemolysis and immune involvement—testing includes newer compatibility checks, a direct antiglobulin test, and comparisons with the donor unit. Urine specimens are examined for hemoglobinuria, which points to intravascular hemolysis, and to monitor renal function. Together, these samples provide a complete picture of whether a reaction is occurring and its severity. Cerebrospinal fluid isn’t part of the evaluation because transfusion reactions don’t typically involve the central nervous system.