In mild von Willebrand disease with mucosal bleeding, which medication should be avoided to reduce bleeding risk?

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Multiple Choice

In mild von Willebrand disease with mucosal bleeding, which medication should be avoided to reduce bleeding risk?

Explanation:
In mild von Willebrand disease, mucosal bleeding happens because there isn’t enough functional von Willebrand factor to help platelets stick to damaged vessels. Treatments that boost or support hemostasis are preferred, such as desmopressin, which releases stored vWF, and tranexamic acid, which helps stabilize clots by inhibiting fibrinolysis. Platelet transfusion is reserved for specific or more severe bleeding situations when other measures aren’t enough. Medications that worsen bleeding risk should be avoided, and nonsteroidal anti-inflammatory drugs fit here because they inhibit cyclooxygenase, lowering thromboxane A2 and impairing platelet aggregation. This makes mucosal bleeding more likely, so avoiding NSAIDs reduces bleeding risk.

In mild von Willebrand disease, mucosal bleeding happens because there isn’t enough functional von Willebrand factor to help platelets stick to damaged vessels. Treatments that boost or support hemostasis are preferred, such as desmopressin, which releases stored vWF, and tranexamic acid, which helps stabilize clots by inhibiting fibrinolysis. Platelet transfusion is reserved for specific or more severe bleeding situations when other measures aren’t enough. Medications that worsen bleeding risk should be avoided, and nonsteroidal anti-inflammatory drugs fit here because they inhibit cyclooxygenase, lowering thromboxane A2 and impairing platelet aggregation. This makes mucosal bleeding more likely, so avoiding NSAIDs reduces bleeding risk.

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